두 약물의 주요 차이점은 작용 계속 기간과 응답 빠르기에 있을 것이다. 비아그라는 섭취 후 약 30분에서 3시간 이내에 효과가 나타나며, 효과 지속 기한은 약 4~6시간입니다. 반면에 시알리스는 섭취 후 약 16분에서 10분 이내에 효능이 나타나며, 효과 계속 기간은 약 34시간에 이릅니다. 이 같은 특징 덕에 시알리스는 "주말 약"으로 불리기도 합니다.
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